Multiple imputation using chained equations for missing data. The performance of multiple imputation for likerttype items with missing data walter leite s. To obtain accurate results, ones imputation model must be congenial to appropriate for ones intended analysis model. In this chapter, i provide stepbystep instructions for performing multiple imputation with schafer s 1997 norm 2. Abstract multiple imputation provides a useful strategy for dealing with data sets that have missing values. Recent advances in analytic methods, such as multiple imputation mi, are taking hold in social work research. Flexible, free software for multilevel multiple imputation.
While the theory of multiple imputation has been known for decades, the implementation is difficult due to the complicated nature of random draws from the posterior distribution. Popular mi software j oint modeling a ssumes multivariate normality, but survey variables tend to be categorical or mixed types loglinear and general location models sc hafer, 1997 are okay when number of variables is small sa y, schafer 1997. Multiple imputation is a popular method for addressing data that are presumed to be missing at random. Automated procedures are widely available in standard software. A simplified framework for using multiple imputation in. Compares solas, sas, mice, splus implementations of imputation. Multiple imputation using chained equations for missing. Missingdata imputation in data analysis using regression and multilevelhierarchical models. Pdf statistical inference in missing data by mcmc and non. In other words, the missing values are filled in m times to generate m complete data sets.
Missing data, multiple imputation and associated software. New computational algorithms and software described in a recent book schafer, 1997 allow us to create proper multiple imputations in complex multivariate settings. An overview of the state of the art center for statistical research and methodology cs rm united states census bureau may16, 2015 views expressed are those of the author and not necessarily those of the u. Multiple imputation by ordered monotone blocks with. Multiple imputation can be used by researchers on many analytic levels. Multiple imputation for multivariate missingdata problems. Natasha beretvas university of florida the university of texas at austin the performance of multiple imputation mi for missing data in likerttype items assuming multivariate normality was assessed using simulation methods. Using multiple imputation to address missing values of. The answer is yes, and one solution is to use multiple imputation. For generating imputations, software to implement the methodology developed by schafer 1997 has been written for the splus mathsoft, 2001 statistical. In recent years, multiple imputation has emerged as a convenient and flexible paradigm for analysing data with missing values. The performance of multiple imputation for likerttype. Schafer 1997 provided a complete exposition of the method in the imputation setting, while gilks. The first part of a multiple imputation analysis is the imputation phase.
Schafer 1997, van buuren and oudshoom 2000 and raghunathan et al. Multiple imputation for continuous and categorical data. Schafer 1997 developed various jm techniques for imputation under the multivariate normal, the loglinear, and the general location model. The idea of multiple imputation for missing data was first proposed by rubin 1977. The performance of multiple imputation for likerttype items. Because in multiple imputation, you only use the parametric model to impute missing incomes. These methods include listwise deletion, pairwise deletion, mean substitution, regression imputation, maximumlikelihood methods and multiple imputation. Although the mi procedure does not offer parameter simulation, the tradeoffs between the two methods schafer 1997, pp. To be sure, often multiple imputation would also use an unrealistic parametric model for the joint distribution of incomes schafer 1997. New computational algorithms and software described in a recent book schafer, 1997a allow us to create proper multiple imputations in complex multivariate settings. Then, each of these completed datasets is analyzed using standard methods for complete data. Multiple imputation of missing values in a cancer mortality.
With multiple imputation, unobserved values are replaced by m 1 independent draws from an imputation model. Instead of lling in a single value for each missing value, a multiple imputation procedure replaces each missing value with a set of plausible values that represent the. A multipleimputation inference is obtained by applying a completedata inference procedure to each of the multiple data sets completed by imputation and then combining these estimates using simple combining rules. Ml and mi are now becoming standard because of implementations in free and commercial software. Avoiding bias due to perfect prediction in multiple. Briefly, the missing data are stochastically imputed m times. There is currently only a limited amount of software for generating multiple imputations under multivariate completedata models and for analyzing multiplyimputed data sets i.
The diversity of the contributions to this special volume provides an impression about the progress of the last decade in the software development in the multiple imputation. Reweighting, long used by survey methodologists, has been proposed for handling missing values in regression models with missing covariates ibrahim, 1990. However, such automated procedures may hide many assumptions and possible difficulties from the view of the data analyst. We carry out multiple imputations using sas proc mi, which implements algorithms given by schafer, 1997. Four studies investigated specialized situations for multiple imputation, such as smallsample degrees of freedom in da barnard and rubin 1999, likertscale data in da leite and beretvas 2010, nonparametric multiple imputation cranmer and gill 20, and variance estimators hughes, sterne, and tilling 2016. Jun 10, 2010 new computational algorithms and software described in a recent book schafer, 1997a allow us to create proper multiple imputations in complex multivariate settings. The last two decades have seen enormous developments in statistical methods for incomplete data. A variety of sources give additional details on multiple imputation allison, 2002, enders, 2010, rubin, 1987, rubin, 1996, schafer and olsen, 1998, schafer, 1997 and sinharay et al. Among these procedures, multiple imputation mi, together with maximum likelihood estimation, is becoming one of the preferred techniques for dealing with. Statistical inference in missing data by mcmc and nonmcmc multiple imputation algorithms.
The purpose of the paper is to propose a method that enables readers to write simple and e. Inferences using the multiply imputed data thus account for the missing data and the uncertainty in the imputations. The multiple imputation process using sas software imputation mechanisms the sas multiple imputation procedures assume that the missing data are missing at random mar, that is, the probability that an observation is missing may depend on the observed values but not the missing values. I examine two approaches to multiple imputation that have been incorporated into widely available software. Yet, in practical terms, those developments have had surprisingly little impact on the way most data analysts. New computational algorithms and software described in a recent book schafer, 1997a allow us to create proper multiple imputations in. Assessing the effects of betweenimputation iterations. Multiple imputation an overview sciencedirect topics. As an alternative to multiple imputation, parameter simulation can also be used to analyze the data for many incompletedata problems.
Some of the most commonlyused software include r packages hmsic harrell 2011, function aregimpute, norm novo and schafer 2010, cat harding, tusell, and schafer 2011, mix schafer 2010 for a variety of techniques to create multiple imputations in continuous, categorical or mixture of continuous and categorical datasets. Multiple imputation mi is a popular way to handle missing data under the missing at random assumption mar little and rubin, 2002. For the imputation of a particular variable, the model should include variables in the completedata model, variables that are correlated with the imputed variable, and variables that are associated with the missingness of the imputed variable schafer 1997, p. Multiple imputation by ordered monotone blocks with application to the anthrax vaccine research program fan li, michela baccini, fabrizia mealli, elizabeth r zell, constantine e frangakis, donald b rubin 1 abstract. Jul 28, 2017 in the literature, multiple imputation is known to be the standard method to handle missing data. With mi, missing values are replaced with values repeatedly drawn from simulated conditional probability distributions schafer, 1997, thus creating multiple versions of the data set. Multivariate imputation by chained equations in r stef van buuren tno karin groothuisoudshoorn university of twente abstract the r package mice imputes incomplete multivariate data by chained equations. The development of diagnostic techniques for multiple imputation, though, has been retarded by the belief that the assumptions of the procedure are untestable from observed data. Imputation and multipleimputation procedures have been used in practice to handle the problem of ignorable nonresponse in. Oct 01, 2010 multiple imputation is a popular way to handle missing data. Although these instructions apply most directly to norm, most of the concepts apply to other mi programs as well. Certainly, multiple imputation is an innovative approach over the traditional ones. In the imputed data, the observed incomes will still follow their empirical.
To learn more about multiple imputation see rubin, 1987, 1996. Multiple imputation, which provides the basis for da, is a general approach to missing data problems that has been shown to produce high quality estimates and reliable standard errors schafer, 1997. In multiple imputation, the parameters means and covariances of the joint distribution of observed and missing. It should be noted that this volume is not intended to be the exclusive source of the multiple imputation software. Multiple imputation for missing data statistics solutions. One approach to incomplete data problems that potentially solves the above issues is multiple imputation rubin, 1987, schafer, 1997. Standalone windows software norm accompanying schafer 1997, operating. New computational algorithms and software described in a recent book schafer, 1997 allow us to create proper multiple imputations in complex multivariate. Adapted from schafer, jl 1997b, introduction to multiple imputations for missing data problems, viewed 6 may 2002. Multiple imputation mi has become a standard statistical technique for dealingwithmissingvalues. Researchers frequently use ad hoc methods of imputation to obtain a complete data set. It is said that da and fcs require betweenimputation iterations to be confidence proper schafer 1997. A method of using multiple imputation in clinical data. When multiple imputation is better than maximum likelihood.
The following is the procedure for conducting the multiple imputation for missing data that was created by. The theoretical details of da are described in detail in schafer 1997, and its application to winlta is presented in hyatt, collins, and. Smallsample degrees of freedom for multicomponent signi. State of the multiple imputation software europe pmc. M imputations completed datasets are generated under some chosen imputation.
Conceived by rubin and described further by little and rubin and schafer, multiple imputation imputes each missing value multiple times. These methods produce estimates that are superior to those of the older methods, but for many researchers, multiple imputation is the general solution to missingdata problems in statistics rubin, 1996. Pdf statistical inference in missing data by mcmc and. Rubin 1987 book on multiple imputation schafer 1997 book on mcmc and multiple imputation for missingdata problems more subjectoriented carpenter, j.
Norm software program schafer, 1999, available free at. The multiple imputation procedure implemented in lisrel 8. Multiple imputation using sas software yang yuan sas institute inc. Although the regression and mcmc methods assume multivariate normality, inferences based on multiple imputation can be robust to departures from the multivariate normality if the amount of missing information is not large schafer 1997, pp. It presents a unified, bayesian approach to the analysis of incomplete multivariate data, covering datasets in which the variables are continuous, categorical, or both. Multiple imputation is a powerful and flexible technique for dealing with missing data. Analysis of incomplete multivariate data helps bridge the gap between theory and practice, making these missingdata tools accessible to a broad audience. The em algorithm and its extensions, multiple imputation, and markov chain monte carlo provide a set of flexible and reliable tools from inference in large classes of missingdata problems. In the commonest approach, the m completed data sets are then analysed using methods appropriate for complete data, and the m results are combined using rubins rules rubin. Sep 16, 20 these methods produce estimates that are superior to those of the older methods, but for many researchers, multiple imputation is the general solution to missingdata problems in statistics rubin, 1996. There is a need to make available workable methodologies for handling missing data.